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Titel:

Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate T17-deviated acute contact dermatitis in human subjects.

Dokumenttyp:
Journal Article; Article
Autor(en):
Garzorz-Stark, Natalie; Lauffer, Felix; Krause, Linda; Thomas, Jenny; Atenhan, Anne; Franz, Regina; Roenneberg, Sophie; Boehner, Alexander; Jargosch, Manja; Batra, Richa; Mueller, Nikola S; Haak, Stefan; Groß, Christina; Groß, Olaf; Traidl-Hoffmann, Claudia; Theis, Fabian J; Schmidt-Weber, Carsten B; Biedermann, Tilo; Eyerich, Stefanie; Eyerich, Kilian
Abstract:
A standardized human model to study early pathogenic events in patients with psoriasis is missing. Activation of Toll-like receptor 7/8 by means of topical application of imiquimod is the most commonly used mouse model of psoriasis.We sought to investigate the potential of a human imiquimod patch test model to resemble human psoriasis.Imiquimod (Aldara 5% cream; 3M Pharmaceuticals, St Paul, Minn) was applied twice a week to the backs of volunteers (n = 18), and development of skin lesions was m...     »
Zeitschriftentitel:
J Allergy Clin Immunol
Jahr:
2018
Band / Volume:
141
Heft / Issue:
4
Seitenangaben Beitrag:
1320-1333.e11
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jaci.2017.07.045
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28935206
Print-ISSN:
0091-6749
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber); Professur für Experimentelle Dermato-Immunologie (Prof. Eyerich)
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