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Title:

Small molecule inhibition of dipeptidyl peptidase-4 enhances bone marrow progenitor cell function and angiogenesis in diabetic wounds.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Whittam, Alexander J; Maan, Zeshaan N; Duscher, Dominik; Barrera, Janos A; Hu, Michael S; Fischer, Lauren H; Khong, Sacha; Kwon, Sun Hyung; Wong, Victor W; Walmsley, Graham G; Giacco, Ferdinando; Januszyk, Michael; Brownlee, Michael; Longaker, Michael T; Gurtner, Geoffrey C
Abstract:
In diabetes, stromal cell-derived factor-1 (SDF-1) expression and progenitor cell recruitment are reduced. Dipeptidyl peptidase-4 (DPP-4) inhibits SDF-1 expression and progenitor cell recruitment. Here we examined the impact of the DPP-4 inhibitor, MK0626, on progenitor cell kinetics in the context of wound healing. Wildtype (WT) murine fibroblasts cultured under high-glucose to reproduce a diabetic microenvironment were exposed to MK0626, glipizide, or no treatment, and SDF-1 expression was mea...     »
Journal title abbreviation:
Transl Res
Year:
2019
Journal volume:
205
Pages contribution:
51-63
Language:
eng
Fulltext / DOI:
doi:10.1016/j.trsl.2018.10.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30452888
Print-ISSN:
1931-5244
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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