Benutzer: Gast  Login
Titel:

Single Molecule Force Spectroscopy Reveals Two-Domain Binding Mode of Pilus-1 Tip Protein RrgA of Streptococcus pneumoniae to Fibronectin.

Dokumenttyp:
Journal Article
Autor(en):
Becke, Tanja D; Ness, Stefan; Gürster, Raimund; Schilling, Arndt F; di Guilmi, Anne-Marie; Sudhop, Stefanie; Hilleringmann, Markus; Clausen-Schaumann, Hauke
Abstract:
For host cell adhesion and invasion, surface piliation procures benefits for bacteria. A detailed investigation of how pili adhere to host cells is therefore a key aspect in understanding their role during infection. Streptococcus pneumoniae TIGR 4, a clinical relevant serotype 4 strain, is capable of expressing pilus-1 with terminal RrgA, an adhesin interacting with host extracellular matrix (ECM) proteins. We used single molecule force spectroscopy to investigate the binding of full-length Rrg...     »
Zeitschriftentitel:
ACS Nano
Jahr:
2018
Band / Volume:
12
Heft / Issue:
1
Seitenangaben Beitrag:
549-558
Sprache:
eng
Volltext / DOI:
doi:10.1021/acsnano.7b07247
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29298375
Print-ISSN:
1936-0851
TUM Einrichtung:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
 BibTeX