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Document type:
journal article 
Author(s):
Gilsbach, Ralf; Schwaderer, Martin; Preissl, Sebastian; Grüning, Björn A; Kranzhöfer, David; Schneider, Pedro; Nührenberg, Thomas G; Mulero-Navarro, Sonia; Weichenhan, Dieter; Braun, Christian; Dreßen, Martina; Jacobs, Adam R; Lahm, Harald; Doenst, Torsten; Backofen, Rolf; Krane, Markus; Gelb, Bruce D; Hein, Lutz 
Title:
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo. 
Abstract:
Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation, and in disease remains unknown. Here, we investigate the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure. We find that prenatal development and postnatal maturation are characterized by a cooperation of act...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2018 
Journal volume:
Journal issue:
Pages contribution:
391 
Language:
eng 
TUM Institution:
Klinik für Herz- und Gefäßchirurgie