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- Document type:
- Journal Article; Article
- Author(s):
- Title:
- Usefulness of Transcatheter Aortic Valve Implantation for Treatment of Pure Native Aortic Valve Regurgitation.
- Abstract:
- Patients with pure native aortic valve regurgitation (NAVR) and increased surgical risk are often denied surgery. This retrospective study aimed to evaluate the "off-label" use of transcatheter heart valves (THV) for the treatment of NAVR. A total of 254 high surgical risk patients with NAVR (age 74 ± 12 years, Society of Thoracic Surgeons risk score 6.6 ± 6.2%) underwent transcatheter aortic valve implantation (TAVI) with early generation (43%) or newer generation (57%) devices at 46 different sites. Device success was significantly higher in patients treated with newer as compared with early generation THV (82% vs 47%, p <0.001). The difference was driven by lower rates of device malpositioning (9% vs 33%) and aortic regurgitation (AR) >= moderate (4% vs 31%) and translated into higher clinical efficacy at 30 days in patients treated with newer as compared with early generation THV (72% vs 56%, p = 0.041). Both THV under- and oversizing were associated with an increased risk of THV malpositioning. In conclusion, TAVI is a feasible treatment strategy in selected high-risk patients with NAVR but is associated with a considerable risk of THV malpositioning and residual AR. Although newer-generation THV are associated with better outcomes, novel devices for the treatment of NAVR are warranted.
- Journal title abbreviation:
- Am J Cardiol
- Year:
- 2018
- Journal volume:
- 122
- Journal issue:
- 6
- Pages contribution:
- 1028-1035
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/j.amjcard.2018.05.044
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/30072124
- Print-ISSN:
- 0002-9149
- TUM Institution:
- Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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