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Titel:

Toll-like receptor 2, hyaluronan, and neutrophils play a key role in plaque erosion: the OPTICO-ACS study.

Dokumenttyp:
Journal Article
Autor(en):
Meteva, Denitsa; Vinci, Ramona; Seppelt, Claudio; Abdelwahed, Youssef S; Pedicino, Daniela; Nelles, Gregor; Skurk, Carsten; Haghikia, Arash; Rauch-Kröhnert, Ursula; Gerhardt, Teresa; Straessler, Elisabeth; Zhao, Yingjie; Golla, Felix; Joner, Michael; Rai, Himanshu; Kratzer, Adelheid; Arnal, Hector Giral; Liuzzo, Giovanna; Klotsche, Jens; Crea, Filippo; Landmesser, Ulf; Leistner, David M; Kränkel, Nicolle
Abstract:
BACKGROUND AND AIMS: In one-third of patients with acute coronary syndrome (ACS), thrombosis occurs despite an intact fibrous cap (IFC) (IFC-ACS, 'plaque erosion'). Recent studies emphasize neutrophils as the immediate inflammatory response in this pathology, but their exact molecular activation patterns are still poorly understood and may represent future therapeutic targets. METHODS AND RESULTS: Thirty-two patients with IFC-ACS and matched patients with ACS with ruptured fibrous cap (RFC) (RFC...     »
Zeitschriftentitel:
Eur Heart J
Jahr:
2023
Band / Volume:
44
Heft / Issue:
38
Seitenangaben Beitrag:
3892-3907
Volltext / DOI:
doi:10.1093/eurheartj/ehad379
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37381760
Print-ISSN:
0195-668X
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)
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