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Titel:

Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation.

Dokumenttyp:
Journal Article; Article
Autor(en):
Sharma, Arun; Zhang, Yuan; Buikema, Jan W; Serpooshan, Vahid; Chirikian, Orlando; Kosaric, Nina; Churko, Jared M; Dzilic, Elda; Shieh, Alice; Burridge, Paul W; Wu, Joseph C; Wu, Sean M
Abstract:
Bioactive lipids such as sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) regulate diverse processes including cell proliferation, differentiation, and migration. However, their roles in cardiac differentiation and cardiomyocyte proliferation have not been explored. Using a 96-well differentiation platform for generating human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) we found that S1P and LPA can independently enhance cardiomyocyte generation when administere...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2018
Band / Volume:
8
Heft / Issue:
1
Seitenangaben Beitrag:
6618
Sprache:
eng
Volltext / DOI:
doi:10.1038/s41598-018-24954-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29700394
Print-ISSN:
2045-2322
TUM Einrichtung:
Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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