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Title:

A cerebrospinal fluid microRNA signature as biomarker for glioblastoma.

Document type:
Journal Article
Author(s):
Akers, Johnny C; Hua, Wei; Li, Hongying; Ramakrishnan, Valya; Yang, Zixiao; Quan, Kai; Zhu, Wei; Li, Jie; Figueroa, Javier; Hirshman, Brian R; Miller, Brittney; Piccioni, David; Ringel, Florian; Komotar, Ricardo; Messer, Karen; Galasko, Douglas R; Hochberg, Fred; Mao, Ying; Carter, Bob S; Chen, Clark C
Abstract:
To develop a cerebrospinal fluid (CSF) miRNA diagnostic biomarker for glioblastoma.Glioblastoma tissue and matched CSF from the same patient (obtained prior to tumor manipulation) were profiled by TaqMan OpenArray Human MicroRNA Panel. CSF miRNA profiles from glioblastoma patients and controls were created from three discovery cohorts and confirmed in two validation cohorts.miRNA profiles from clinical CSF correlated with those found in glioblastoma tissues. Comparison of CSF miRNA profiles betw...     »
Journal title abbreviation:
Oncotarget
Year:
2017
Journal volume:
8
Journal issue:
40
Pages contribution:
68769-68779
Language:
eng
Fulltext / DOI:
doi:10.18632/oncotarget.18332
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28978155
TUM Institution:
Neurochirurgische Klinik und Poliklinik
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