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Titel:

AMPLIFY-NEOVAC: a randomized, 3-arm multicenter phase I trial to assess safety, tolerability and immunogenicity of IDH1-vac combined with an immune checkpoint inhibitor targeting programmed death-ligand 1 in isocitrate dehydrogenase 1 mutant gliomas.

Dokumenttyp:
Journal Article
Autor(en):
Bunse, Lukas; Rupp, Anne-Kathleen; Poschke, Isabel; Bunse, Theresa; Lindner, Katharina; Wick, Antje; Blobner, Jens; Misch, Martin; Tabatabai, Ghazaleh; Glas, Martin; Schnell, Oliver; Gempt, Jens; Denk, Monika; Reifenberger, Guido; Bendszus, Martin; Wuchter, Patrick; Steinbach, Joachim P; Wick, Wolfgang; Platten, Michael
Abstract:
INTRODUCTION: Isocitrate dehydrogenase (IDH) mutations are disease-defining mutations in IDH-mutant astrocytomas and IDH-mutant and 1p/19q-codeleted oligodendrogliomas. In more than 80% of these tumors, point mutations in IDH type 1 (IDH1) lead to expression of the tumor-specific protein IDH1R132H. IDH1R132H harbors a major histocompatibility complex class II (MHCII)-restricted neoantigen that was safely and successfully targeted in a first-in human clinical phase 1 trial evaluating an IDH1R132H...     »
Zeitschriftentitel:
Neurol Res Pract
Jahr:
2022
Band / Volume:
4
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s42466-022-00184-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35599302
TUM Einrichtung:
Klinik und Poliklinik für Neurochirurgie
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