High-Protein, Low-Glycaemic Meal Replacement Improves Physical Health-Related Quality of Life in High-Risk Persons for Metabolic Syndrome-A Subanalysis of the Randomised-Controlled ACOORH Trial.

Kempf, Kerstin; Röhling, Martin; Banzer, Winfried; Braumann, Klaus Michael; Halle, Martin; Schaller, Nina; McCarthy, David; Predel, Hans Georg; Schenkenberger, Isabelle; Tan, Susanne; Toplak, Hermann; Martin, Stephan; Berg, Aloys; On Behalf Of The Acoorh Study Group

doi:10.3390/nu14153161

Poliklinik für Präventive Sportmedizin und Sportkardiologie (Prof. Halle)

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Document type:: Article; Journal Article; Multicenter Study; Randomized Controlled Trial
Author(s):: Kempf, Kerstin; Röhling, Martin; Banzer, Winfried; Braumann, Klaus Michael; Halle, Martin; Schaller, Nina; McCarthy, David; Predel, Hans Georg; Schenkenberger, Isabelle; Tan, Susanne; Toplak, Hermann; Martin, Stephan; Berg, Aloys; On Behalf Of The Acoorh Study Group
Title:: High-Protein, Low-Glycaemic Meal Replacement Improves Physical Health-Related Quality of Life in High-Risk Persons for Metabolic Syndrome-A Subanalysis of the Randomised-Controlled ACOORH Trial.
Abstract:: While obesity impairs health-related quality of life (HRQOL), lifestyle interventions targeting weight reduction have been effective in improving HRQOL. Therefore, we hypothesised that a meal replacement-based lifestyle intervention, which has been shown to successfully reduce weight, would also improve HRQOL more effectively than a lifestyle intervention alone. In the international, multicenter, randomised-controlled ACOORH-trial (Almased-Concept-against- Overweight-and-Obesity-and-Related-Health-Risk), overweight or obese participants with elevated risk for metabolic syndrome (n = 463) were randomised into two groups. Both groups received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement for 6 months. HRQOL was estimated at baseline, after 3 and 12 months, using the SF-36 questionnaire, and all datasets providing HRQOL data (n = 263) were included in this predefined subanalysis. Stronger improvements in the physical component summary (PCS) were observed in the intervention compared to the control group, peaking after 3 months (estimated treatment difference 2.7 [1.2; 4.2]; p < 0.0001), but also in the long-term. Multiple regression analysis demonstrated that insulin levels and the achieved weight loss were associated with the mental component summary (MCS) after 12 months (p < 0.05). Thus, meal replacement-based lifestyle intervention is not only effective in weight reduction but, concomitantly, in enhancing HRQOL.
Journal title abbreviation:: Nutrients
Year:: 2022
Journal volume:: 14
Journal issue:: 15
Fulltext / DOI:: doi:10.3390/nu14153161
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/35956337
TUM Institution:: Poliklinik für Präventive und Rehabilitative Sportmedizin
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Poliklinik für Präventive Sportmedizin und Sportkardiologie (Prof. Halle)2022