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Titel:

SDF-1/CXCR4 expression is an independent negative prognostic biomarker in patients with head and neck cancer after primary radiochemotherapy.

Dokumenttyp:
Journal Article; Article; Proceedings Paper
Autor(en):
De-Colle, Chiara; Menegakis, Apostolos; Mönnich, David; Welz, Stefan; Boeke, Simon; Sipos, Bence; Fend, Falko; Mauz, Paul-Stefan; Tinhofer, Inge; Budach, Volker; Abu Jawad, Jehad; Stuschke, Martin; Balermpas, Panagiotis; Rödel, Claus; Grosu, Anca-Ligia; Abdollahi, Amir; Debus, Jürgen; Belka, Claus; Ganswindt, Ute; Pigorsch, Steffi; Combs, Stephanie E; Lohaus, Fabian; Linge, Annett; Krause, Mechthild; Baumann, Michael; Zips, Daniel
Abstract:
INTRODUCTION: Preclinical and clinical data suggest that the chemokine pathway governed by SDF-1 and CXCR4 contributes to a resistant phenotype. This retrospective biomarker study aims to explore the specific prognostic value of SDF-1 and CXCR4 expression in locally advanced head and neck squamous cell carcinomas (HNSCC) treated with primary radiochemotherapy (RT-CT). MATERIAL AND METHODS: Biopsies from 141 HNSCC tumours of the oral cavity, oropharynx and hypopharynx were evaluated for SDF-1 and...     »
Zeitschriftentitel:
Radiother Oncol
Jahr:
2018
Band / Volume:
126
Heft / Issue:
1
Seitenangaben Beitrag:
125-131
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.radonc.2017.10.008
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29061496
Print-ISSN:
0167-8140
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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