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Title:

Immunohistochemical, Flow Cytometric, and ELISA-Based Analyses of Intracellular, Membrane-Expressed, and Extracellular Hsp70 as Cancer Biomarkers.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Dezfouli, Ali Bashiri; Stangl, Stefan; Foulds, Gemma A; Lennartz, Philipp; Pilkington, Geoffrey J; Pockley, A Graham; Multhoff, Gabriele
Abstract:
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumor cells and thus might serve as a tumor-specific biomarker of aggressive disease and/or therapeutic resistance. We have previously shown that, in contrast to normal cells, tumor cells present Hsp70 on their plasma membrane. In order to elucidate the role of intracellular, membrane-bound and extracellular Hsp70 as a potential tumor biomarker in cancer, herein we describe p...     »
Journal title abbreviation:
Methods Mol Biol
Year:
2023
Journal volume:
2693
Pages contribution:
307-324
Fulltext / DOI:
doi:10.1007/978-1-0716-3342-7_23
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37540444
Print-ISSN:
1064-3745
TUM Institution:
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)
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