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Title:

Membrane heat shock protein 70: a theranostic target for cancer therapy.

Document type:
Journal Article; Review; Journal Article; Review
Author(s):
Shevtsov, Maxim; Huile, Gao; Multhoff, Gabriele
Abstract:
Members of the 70 kDa stress protein family are found in nearly all subcellular compartments of nucleated cells where they fulfil a number of chaperoning functions. Heat shock protein 70 (HSP70), also termed HSPA1A, the major stress-inducible member of this family is overexpressed in a large variety of different tumour types. Apart from its intracellular localization, a tumour-selective HSP70 membrane expression has been determined. A membrane HSP70-positive tumour phenotype is associated with a...     »
Journal title abbreviation:
Philos Trans R Soc Lond B Biol Sci
Year:
2018
Journal volume:
373
Journal issue:
1738
Language:
eng
Fulltext / DOI:
doi:10.1098/rstb.2016.0526
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29203711
Print-ISSN:
0962-8436
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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