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Title:

A new look at Hsp70 activity in phosphatidylserine-enriched membranes: chaperone-induced quasi-interdigitated lipid phase.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Tagaeva, Ruslana; Efimova, Svetlana; Ischenko, Alexander; Zhakhov, Alexander; Shevtsov, Maxim; Ostroumova, Olga
Abstract:
70 kDa heat shock protein Hsp70 (also termed HSP70A1A) is the major stress-inducible member of the HSP70 chaperone family, which is present on the plasma membranes of various tumor cells, but not on the membranes of the corresponding normal cells. The exact mechanisms of Hsp70 anchoring in the membrane and its membrane-related functions are still under debate, since the protein does not contain consensus signal sequence responsible for translocation from the cytosol to the lipid bilayer. The pre...     »
Journal title abbreviation:
Sci Rep
Year:
2023
Journal volume:
13
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-023-46131-x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37932471
Print-ISSN:
2045-2322
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)
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