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Document type:
journal article 
Author(s):
Schottelius, Margret; Osl, Theresa; Poschenrieder, Andreas; Hoffmann, Frauke; Beykan, Seval; Hänscheid, Heribert; Schirbel, Andreas; Buck, Andreas K; Kropf, Saskia; Schwaiger, Markus; Keller, Ulrich; Lassmann, Michael; Wester, Hans-Jürgen 
Title:
[Lu]pentixather: Comprehensive Preclinical Characterization of a First CXCR4-directed Endoradiotherapeutic Agent. 
Abstract:
Based on the clinical relevance of the chemokine receptor 4 (CXCR4) as a molecular target in cancer and on the success of [Ga]pentixafor as an imaging probe for high-contrast visualization of CXCR4-expression, the spectrum of clinical CXCR4-targeting was expanded towards peptide receptor radionuclide therapy (PRRT) by the development of [Lu]pentixather. CXCR4 affinity, binding specificity, hCXCR4 selectivity and internalization efficiency of [Lu]pentixather were evaluated using different human...    »
 
Journal title abbreviation:
Theranostics 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
2350-2362 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Innere Medizin III