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- Title:
Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.
- Document type:
- Letter; Letter; Research Support, Non-U.S. Gov't
- Author(s):
- Poeck, Hendrik; Wintges, Alexander; Dahl, Sarah; Bassermann, Florian; Haas, Tobias; Heidegger, Simon
- Abstract:
- Immunogenic cancer therapies, including radiation and hypomethylating agents, such as 5-azacytidine, rely on tumor cell-intrinsic activation of the RNA receptor RIG-I for their synergism with immune checkpoint inhibitors. Possible RIG-I ligands are small nuclear RNA (snRNA) and endogenous retroviral elements (ERV) leaking from the nucleus during programmed cell death.
- Journal title abbreviation:
- Eur J Immunol
- Year:
- 2021
- Journal volume:
- 51
- Journal issue:
- 6
- Pages contribution:
- 1531-1534
- Fulltext / DOI:
- doi:10.1002/eji.202049158
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/33733474
- Print-ISSN:
- 0014-2980
- TUM Institution:
- III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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