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Title:

Synthesis and Preclinical Evaluation of a 68Ga-Labeled Adnectin, 68Ga-BMS-986192, as a PET Agent for Imaging PD-L1 Expression.

Document type:
Journal Article
Author(s):
Robu, Stephanie; Richter, Antonia; Gosmann, Dario; Seidl, Christof; Leung, David; Hayes, Wendy; Cohen, Daniel; Morin, Paul; Donnelly, David J; Lipovšek, Daša; Bonacorsi, Samuel J; Smith, Adam; Steiger, Katja; Aulehner, Christina; Krackhardt, Angela M; Weber, Wolfgang A
Abstract:
Blocking the interaction of the immune checkpoint molecule programmed cell death protein-1 and its ligand, PD-L1, using specific antibodies has been a major breakthrough for immune oncology. Whole-body PD-L1 expression PET imaging may potentially allow for a better prediction of response to programmed cell death protein-1-targeted therapies. Imaging of PD-L1 expression is feasible by PET with the adnectin protein 18F-BMS-986192. However, radiofluorination of proteins such as BMS-986192 remains c...     »
Journal title abbreviation:
J Nucl Med
Year:
2021
Journal volume:
62
Journal issue:
9
Pages contribution:
1228-1234
Fulltext / DOI:
doi:10.2967/jnumed.120.258384
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33517324
Print-ISSN:
0161-5505
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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