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Title:

The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Meinhardt, Anna-Lena; Munkhbaatar, Enkhtsetseg; Höckendorf, Ulrike; Dietzen, Michelle; Dechant, Marta; Anton, Martina; Jacob, Anne; Steiger, Katja; Weichert, Wilko; Brcic, Luka; McGranahan, Nicholas; Branca, Caterina; Kaufmann, Thomas; Dengler, Michael A; Jost, Philipp J
Abstract:
A variety of cancer entities are driven by KRAS mutations, which remain difficult to target clinically. Survival pathways, such as resistance to cell death, may represent a promising treatment approach in KRAS mutated cancers. Based on the frequently observed genomic deletions of BCL-2-related ovarian killer (BOK) in cancer patients, we explored the function of BOK in a mutant KrasG12D-driven murine model of lung cancer. Using KrasG12D/+ Bok-/- mice, we observed an overall tumor-promoting functi...     »
Journal title abbreviation:
Oncogene
Year:
2022
Journal volume:
41
Journal issue:
9
Pages contribution:
1376-1382
Fulltext / DOI:
doi:10.1038/s41388-021-02161-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35091677
Print-ISSN:
0950-9232
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann); Roman Herzog Comprehensive Cancer Center
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