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Titel:

Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis.

Dokumenttyp:
Journal Article
Autor(en):
Wenk, Catharina; Garz, Anne-Kathrin; Grath, Sonja; Huberle, Christina; Witham, Denis; Weickert, Marie; Malinverni, Roberto; Niggemeyer, Julia; Kyncl, Michèle; Hecker, Judith; Pagel, Charlotta; Mulholland, Christopher B; Müller-Thomas, Catharina; Leonhardt, Heinrich; Bassermann, Florian; Oostendorp, Robert A J; Metzeler, Klaus H; Buschbeck, Marcus; Götze, Katharina S
Abstract:
Mesenchymal stromal cells (MSCs) are crucial components of the bone marrow (BM) microenvironment essential for regulating self-renewal, survival, and differentiation of hematopoietic stem/progenitor cells (HSPCs) in the stem cell niche. MSCs are functionally altered in myelodysplastic syndromes (MDS) and exhibit an altered methylome compared with MSCs from healthy controls, thus contributing to disease progression. To determine whether MSCs are amenable to epigenetic therapy and if this affects...     »
Zeitschriftentitel:
Blood Adv
Jahr:
2018
Band / Volume:
2
Heft / Issue:
23
Seitenangaben Beitrag:
3447-3461
Volltext / DOI:
doi:10.1182/bloodadvances.2018022053
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30518537
Print-ISSN:
2473-9529
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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