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Titel:

Casein kinase 1.2 over expression restores stress resistance to Leishmania donovani HSP23 null mutants.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kröber-Boncardo, Constanze; Lorenzen, Stephan; Brinker, Christine; Clos, Joachim
Abstract:
Leishmania donovani is a trypanosomatidic parasite and causes the lethal kala-azar fever, a neglected tropical disease. The Trypanosomatida are devoid of transcriptional gene regulation and rely on gene copy number variations and translational control for their adaption to changing conditions. To survive at mammalian tissue temperatures, L. donovani relies on the small heat shock protein HSP23, the loss of which renders the parasites stress sensitive and impairs their proliferation. Here, we ana...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2020
Band / Volume:
10
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41598-020-72724-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32994468
Print-ISSN:
2045-2322
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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