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Titel:

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Jayavelu, Ashok Kumar; Schnöder, Tina M; Perner, Florian; Herzog, Carolin; Meiler, Arno; Krishnamoorthy, Gurumoorthy; Huber, Nicolas; Mohr, Juliane; Edelmann-Stephan, Bärbel; Austin, Rebecca; Brandt, Sabine; Palandri, Francesca; Schröder, Nicolas; Isermann, Berend; Edlich, Frank; Sinha, Amit U; Ungelenk, Martin; Hübner, Christian A; Zeiser, Robert; Rahmig, Susann; Waskow, Claudia; Coldham, Iain; Ernst, Thomas; Hochhaus, Andreas; Jilg, Stefanie; Jost, Philipp J; Mullally, Ann; Bullinger, Lars; Me...     »
Abstract:
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells1,2. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system3,4 and in haematopoietic cancers5. JAK2 mutations constitutively activate downstream signalling and are drivers of myeloproliferative neoplasm (MPN). In clinical use, JAK inhibitors have mixed effects on the overall disease burden of JAK2-mutated clones6,7, prompting us to investigate the mechanism underlying dise...     »
Zeitschriftentitel:
Nature
Jahr:
2020
Band / Volume:
588
Heft / Issue:
7836
Seitenangaben Beitrag:
157-163
Volltext / DOI:
doi:10.1038/s41586-020-2968-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33239784
Print-ISSN:
0028-0836
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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