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Title:

Opioids for chronic low back pain: An updated systematic review and meta-analysis of efficacy, tolerability and safety in randomized placebo-controlled studies of at least 4 weeks of double-blind duration

Document type:
Review
Author(s):
Petzke, Frank; Klose, Petra; Welsch, Patrick; Sommer, Claudia; Haeuser, Winfried
Abstract:
Background and Objective This updated systematic review evaluated the efficacy, tolerability and safety of opioids compared to placebo in non-malignant chronic low back pain. Databases and Data Treatment Clinicaltrials.gov, CENTRAL, MEDLINE and PsycINFO were searched from October 2013 to May 2019. Randomized controlled trials comparing opioids with placebo and at least 4 weeks of double-blinded duration were analysed. Primary outcomes were pain relief of 50% or greater, disability, tolerability...     »
Journal title abbreviation:
Eur J Pain
Year:
2020
Journal volume:
24
Journal issue:
3
Pages contribution:
497-517
Fulltext / DOI:
doi:10.1002/ejp.1519
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31823442
Print-ISSN:
1090-3801
TUM Institution:
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
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