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Title:

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Stitziel, Nathan O; Stirrups, Kathleen E; Masca, Nicholas G D; Erdmann, Jeanette; Ferrario, Paola G; König, Inke R; Weeke, Peter E; Webb, Thomas R; Auer, Paul L; Schick, Ursula M; Lu, Yingchang; Zhang, He; Dube, Marie-Pierre; Goel, Anuj; Farrall, Martin; Peloso, Gina M; Won, Hong-Hee; Do, Ron; van Iperen, Erik; Kanoni, Stavroula; Kruppa, Jochen; Mahajan, Anubha; Scott, Robert A; Willenberg, Christina; Braund, Peter S; van Capelleveen, Julian C; Doney, Alex S F; Donnelly, Louise A; Asselta, Rosan...     »
Abstract:
The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets.Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequencing, we studied the effects of loss-of-function mutations in selected genes.We confirmed previously observed significan...     »
Journal title abbreviation:
N Engl J Med
Year:
2016
Journal volume:
374
Journal issue:
12
Pages contribution:
1134-44
Language:
eng
Fulltext / DOI:
doi:10.1056/NEJMoa1507652
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26934567
Print-ISSN:
0028-4793
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Humangenetik; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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