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Title:

Combined Chemisorption and Complexation Generate siRNA Nanocarriers with Biophysics Optimized for Efficient Gene Knockdown and Air-Blood Barrier Crossing.

Document type:
Article; Journal Article
Author(s):
Taschauer, Alexander; Polzer, Wolfram; Pöschl, Stefan; Metz, Slavica; Tepe, Nathalie; Decker, Simon; Cyran, Norbert; Scholda, Julia; Maier, Julia; Bloß, Hermann; Anton, Martina; Hofmann, Thilo; Ogris, Manfred; Sami, Haider
Abstract:
Current nucleic acid (NA) nanotherapeutic approaches face challenges because of shortcomings such as limited control on loading efficiency, complex formulation procedure involving purification steps, low load of NA cargo per nanoparticle, endosomal trapping, and hampered release inside the cell. When combined, these factors significantly limit the amount of biologically active NA delivered per cell in vitro, delivered dosages in vivo for a prolonged biological effect, and the upscalability poten...     »
Journal title abbreviation:
ACS Appl Mater Interfaces
Year:
2020
Journal volume:
12
Journal issue:
27
Pages contribution:
30095-30111
Fulltext / DOI:
doi:10.1021/acsami.0c06608
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32515194
Print-ISSN:
1944-8244
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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