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Title:

Oncogenic Linear Collagen VI of Invasive Breast Cancer Is Induced by CCL5.

Document type:
Journal Article
Author(s):
Brett, Elizabeth; Sauter, Matthias; Timmins, Éadaoin; Azimzadeh, Omid; Rosemann, Michael; Merl-Pham, Juliane; Hauck, Stefanie M; Nelson, Peter J; Becker, Karl Friedrich; Schunn, Ilse; Lowery, Aoife; Kerin, Michael J; Atkinson, Michael; Krüger, Achim; Machens, Hans-Günther; Duscher, Dominik
Abstract:
The triple-negative breast tumor boundary is made of aligned, linear collagen. The pro-oncogenic impact of linear collagen is well established; however, its mechanism of formation is unknown. An in vitro analogue of the tumor border is created by a co-culture of MDA-MB-231 cells, adipose derived stem cells, and dermal fibroblasts. Decellularization of this co-culture after seven days reveals an extracellular matrix that is linear in fashion, high in pro-oncogenic collagen type VI, and able to p...     »
Journal title abbreviation:
J. Clin. Med.
Year:
2020
Journal volume:
9
Journal issue:
4
Fulltext / DOI:
doi:10.3390/jcm9040991
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32252260
Print-ISSN:
2077-0383
TUM Institution:
602; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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