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Title:

Inhibition of LTβR signalling activates WNT-induced regeneration in lung.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Conlon, Thomas M; John-Schuster, Gerrit; Heide, Danijela; Pfister, Dominik; Lehmann, Mareike; Hu, Yan; Ertüz, Zeynep; Lopez, Martin A; Ansari, Meshal; Strunz, Maximilian; Mayr, Christoph; Angelidis, Ilias; Ciminieri, Chiara; Costa, Rita; Kohlhepp, Marlene Sophia; Guillot, Adrien; Günes, Gizem; Jeridi, Aicha; Funk, Maja C; Beroshvili, Giorgi; Prokosch, Sandra; Hetzer, Jenny; Verleden, Stijn E; Alsafadi, Hani; Lindner, Michael; Burgstaller, Gerald; Becker, Lore; Irmler, Martin; Dudek, Michael; Jan...     »
Abstract:
Lymphotoxin β-receptor (LTβR) signalling promotes lymphoid neogenesis and the development of tertiary lymphoid structures1,2, which are associated with severe chronic inflammatory diseases that span several organ systems3-6. How LTβR signalling drives chronic tissue damage particularly in the lung, the mechanism(s) that regulate this process, and whether LTβR blockade might be of therapeutic value have remained unclear. Here we demonstrate increased expression of LTβR ligands in adaptive and inn...     »
Journal title abbreviation:
Nature
Year:
2020
Journal volume:
588
Journal issue:
7836
Pages contribution:
151-156
Fulltext / DOI:
doi:10.1038/s41586-020-2882-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33149305
Print-ISSN:
0028-0836
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Roman Herzog Comprehensive Cancer Center
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