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Titel:

TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer.

Dokumenttyp:
Journal Article
Autor(en):
Hermann, Chris D; Schoeps, Benjamin; Eckfeld, Celina; Munkhbaatar, Enkhtsetseg; Kniep, Lukas; Prokopchuk, Olga; Wirges, Nils; Steiger, Katja; Häußler, Daniel; Knolle, Percy; Poulton, Emily; Khokha, Rama; Grünwald, Barbara T; Demir, Ihsan Ekin; Krüger, Achim
Abstract:
Sex disparity in cancer is so far inadequately considered, and components of its basis are rather unknown. We reveal that male versus female pancreatic cancer (PC) patients and mice show shortened survival, more frequent liver metastasis, and elevated hepatic metastasis-promoting gene expression. Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in patient-derived pancreatic tumors. Male-specific up-regulation of systemic TIMP1 was...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2021
Band / Volume:
218
Heft / Issue:
11
Volltext / DOI:
doi:10.1084/jem.20210911
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34533565
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Chirurgie; Roman Herzog Comprehensive Cancer Center
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