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Titel:

Dysregulated PI3K Signaling in B Cells of CVID Patients.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Harder, Ina; Münchhalfen, Matthias; Andrieux, Geoffroy; Boerries, Melanie; Grimbacher, Bodo; Eibel, Hermann; Maccari, Maria Elena; Ehl, Stephan; Wienands, Jürgen; Jellusova, Julia; Warnatz, Klaus; Keller, Baerbel
Abstract:
The altered wiring of signaling pathways downstream of antigen receptors of T and B cells contributes to the dysregulation of the adaptive immune system, potentially causing immunodeficiency and autoimmunity. In humans, the investigation of such complex systems benefits from nature's experiments in patients with genetically defined primary immunodeficiencies. Disturbed B-cell receptor (BCR) signaling in a subgroup of common variable immunodeficiency (CVID) patients with immune dysregulation and...     »
Zeitschriftentitel:
Cells
Jahr:
2022
Band / Volume:
11
Heft / Issue:
3
Volltext / DOI:
doi:10.3390/cells11030464
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35159274
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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