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Title:

Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Patzelt, Thomas; Keppler, Selina J; Gorka, Oliver; Thoene, Silvia; Wartewig, Tim; Reth, Michael; Förster, Irmgard; Lang, Roland; Buchner, Maike; Ruland, Jürgen
Abstract:
The transcription factor Foxp1 is critical for early B cell development. Despite frequent deregulation of Foxp1 in B cell lymphoma, the physiological functions of Foxp1 in mature B cells remain unknown. Here, we used conditional gene targeting in the B cell lineage and report that Foxp1 disruption in developing and mature B cells results in reduced numbers and frequencies of follicular and B-1 B cells and in impaired antibody production upon T cell-independent immunization in vivo. Moreover, Fox...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2018
Journal volume:
115
Journal issue:
12
Pages contribution:
3120-3125
Fulltext / DOI:
doi:10.1073/pnas.1711335115
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29507226
Print-ISSN:
0027-8424
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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