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Title:

Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Peeters, Rens; Cuenca-Escalona, Jorge; Zaal, Esther A; Hoekstra, Anna T; Balvert, Anouk C G; Vidal-Manrique, Marcos; Blomberg, Niek; van Deventer, Sjoerd J; Stienstra, Rinke; Jellusova, Julia; Giera, Martin; Hannibal, Luciana; Spiekerkoetter, Ute; Ter Beest, Martin; Berkers, Celia R; van Spriel, Annemiek B
Abstract:
The importance of fatty acid (FA) metabolism in cancer is well-established, yet the mechanisms underlying metabolic reprogramming remain elusive. Here, we identify tetraspanin CD37, a prognostic marker for aggressive B-cell lymphoma, as essential membrane-localized inhibitor of FA metabolism. Deletion of CD37 on lymphoma cells results in increased FA oxidation shown by functional assays and metabolomics. Furthermore, CD37-negative lymphomas selectively deplete palmitate from serum in mouse studi...     »
Journal title abbreviation:
Nat Commun
Year:
2022
Journal volume:
13
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-022-33138-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36100608
Print-ISSN:
2041-1723
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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