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Title:

CD20 as a gatekeeper of the resting state of human B cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kläsener, Kathrin; Jellusova, Julia; Andrieux, Geoffroy; Salzer, Ulrich; Böhler, Chiara; Steiner, Sebastian N; Albinus, Jonas B; Cavallari, Marco; Süß, Beatrix; Voll, Reinhard E; Boerries, Melanie; Wollscheid, Bernd; Reth, Michael
Abstract:
CD20 is a B cell-specific membrane protein and represents an attractive target for therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies for B cell depletion therapies, the biological function of their target remains unclear. Here, we demonstrate that CD20 controls the nanoscale organization of receptors on the surface of resting B lymphocytes. CRISPR/Cas9-mediated ablation of CD20 in resting B cells resulted in relocalization and interaction of the IgM-class B cell antigen re...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2021
Journal volume:
118
Journal issue:
7
Fulltext / DOI:
doi:10.1073/pnas.2021342118
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33563755
Print-ISSN:
0027-8424
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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