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Title:

The Wanderings of Gut-Derived IgA Plasma Cells: Impact on Systemic Immune Responses.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Keppler, Selina J; Goess, Marie Christine; Heinze, Julia M
Abstract:
Humoral immunity is mainly mediated by a B cell population highly specialized to synthesize and secrete large quantities of antibodies - the antibody-secreting cells (ASC). In the gastrointestinal environment, a mixture of foreign antigens from the diet, commensal microbiota as well as occasional harmful pathogens lead to a constant differentiation of B cells into ASC. Due to this permanent immune response, more than 80% of mammalian ASC reside in the gut, of which most express immunoglobulin A...     »
Journal title abbreviation:
Front Immunol
Year:
2021
Journal volume:
12
Fulltext / DOI:
doi:10.3389/fimmu.2021.670290
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33936114
Print-ISSN:
1664-3224
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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