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Title:

The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Raulf, Marie-Kristin; Johannssen, Timo; Matthiesen, Svea; Neumann, Konstantin; Hachenberg, Severin; Mayer-Lambertz, Sabine; Steinbeis, Fridolin; Hegermann, Jan; Seeberger, Peter H; Baumgärtner, Wolfgang; Strube, Christina; Ruland, Jürgen; Lepenies, Bernd
Abstract:
Malaria represents a major cause of death from infectious disease. Hemozoin is a Plasmodium-derived product that contributes to progression of cerebral malaria. However, there is a gap of knowledge regarding how hemozoin is recognized by innate immunity. Myeloid C-type lectin receptors (CLRs) encompass a family of carbohydrate-binding receptors that act as pattern recognition receptors in innate immunity. In the present study, we identify the CLR CLEC12A as a receptor for hemozoin. Dendritic cel...     »
Journal title abbreviation:
Cell Rep
Year:
2019
Journal volume:
28
Journal issue:
1
Pages contribution:
30-38.e5
Fulltext / DOI:
doi:10.1016/j.celrep.2019.06.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31269448
Print-ISSN:
2211-1247
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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