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Title:

Prdm6 controls heart development by regulating neural crest cell differentiation and migration.

Document type:
Journal Article; Research Support, N.I.H., Extramural
Author(s):
Hong, Lingjuan; Li, Na; Gasque, Victor; Mehta, Sameet; Ye, Lupeng; Wu, Yinyu; Li, Jinyu; Gewies, Andreas; Ruland, Jürgen; Hirschi, Karen K; Eichmann, Anne; Hendry, Caroline; van Dijk, David; Mani, Arya
Abstract:
The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates is still poorly understood. Here, we identified Prdm6 as an epigenetic modifier that temporally and spatially regulates the expression of NCC specifiers and determines the fate of a subset of migrating cardiac NCCs (CNCCs). Using transcriptomic analysis and genetic and fate mapping approaches in transgenic mice, we showed that disruption of Prdm6 was associated with impaired CNCC differentiation, delami...     »
Journal title abbreviation:
JCI Insight
Year:
2022
Journal volume:
7
Journal issue:
4
Fulltext / DOI:
doi:10.1172/jci.insight.156046
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35108221
Print-ISSN:
2379-3708
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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