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Titel:

PD-1 Tumor Suppressor Signaling in T Cell Lymphomas.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Wartewig, Tim; Ruland, Jürgen
Abstract:
The inhibitory receptor PD-1 is critical to balancing antigen-induced T cell activation; its inhibition is currently being explored to enhance antitumor T cell immunity with certain successful outcomes. However, PD-1 has also emerged as a central tumor suppressor in T cell lymphomas, where the tumor cell originates from a T cell itself. These aggressive cancers are frequently characterized by oncogenic mutations in T cell receptor (TCR) signaling pathways. PD-1 activity within malignant T cells...     »
Zeitschriftentitel:
Trends Immunol
Jahr:
2019
Band / Volume:
40
Heft / Issue:
5
Seitenangaben Beitrag:
403-414
Volltext / DOI:
doi:10.1016/j.it.2019.03.005
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30979616
Print-ISSN:
1471-4906
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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