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Title:

Definition and validation of serum biomarkers for optimal differentiation of hyperferritinaemic cytokine storm conditions in children: a retrospective cohort study

Document type:
Article
Author(s):
Kessel, Christoph; Fall, Ndate; Grom, Alexei; de Jager, Wilco; Vastert, Sebastiaan; Strippoli, Raffaele; Bracaglia, Claudia; Sundberg, Erik; Horne, AnnaCarin; Ehl, Stephan; Ammann, Sandra; Wouters, Carine; Lehmberg, Kai; De Benedetti, Fabrizio; Park, Carolin; Hinze, Claas; Wittkowski, Helmut; Kessel, Katharina; Beutel, Karin; Foell, Dirk; Holzinger, Dirk
Abstract:
Background Cytokine storm syndromes are life-threatening complications that can occur in children with rheumatic conditions (macrophage activation syndrome [MAS]), inherited cytotoxicity defects (ie, primary haemophagocytic lymphohistiocytosis [HLH]), or as a result of infection or malignancies (ie, secondary HLH). To adequately steer treatment, an early and clear discrimination of these entities is essential. We aimed to define and validate serum biomarker profiles that can differentiate betwee...     »
Journal title abbreviation:
Lancet Rheumatol.
Year:
2021
Journal volume:
3
Journal issue:
8
Pages contribution:
E563-E573
Fulltext / DOI:
doi:10.1016/S2665-9913(21)00115-6
Print-ISSN:
2665-9913
TUM Institution:
Klinik und Poliklinik für Kinder- und Jugendmedizin
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