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Title:

Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study.

Document type:
Journal Article; Research Support, N.I.H., Extramural
Author(s):
Li, Qian; Parikh, Hemang; Butterworth, Martha D; Lernmark, Åke; Hagopian, William; Rewers, Marian; She, Jin-Xiong; Toppari, Jorma; Ziegler, Anette-G; Akolkar, Beena; Fiehn, Oliver; Fan, Sili; Krischer, Jeffrey P
Abstract:
Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age. Metabolic profile changes over time may imply responses to exposures and signal development of the first IA. Our present research in The Environmental Determinants of Diabetes in the Young (TEDDY) study aimed to identify metabolome-wide signals preceding the first IA against GAD (GADA-first) or against insulin (IAA-first). We profiled me...     »
Journal title abbreviation:
Diabetes
Year:
2020
Journal volume:
69
Journal issue:
3
Pages contribution:
465-476
Fulltext / DOI:
doi:10.2337/db19-0756
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32029481
Print-ISSN:
0012-1797
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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