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Titel:

Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural
Autor(en):
Li, Qian; Parikh, Hemang; Butterworth, Martha D; Lernmark, Åke; Hagopian, William; Rewers, Marian; She, Jin-Xiong; Toppari, Jorma; Ziegler, Anette-G; Akolkar, Beena; Fiehn, Oliver; Fan, Sili; Krischer, Jeffrey P
Abstract:
Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age. Metabolic profile changes over time may imply responses to exposures and signal development of the first IA. Our present research in The Environmental Determinants of Diabetes in the Young (TEDDY) study aimed to identify metabolome-wide signals preceding the first IA against GAD (GADA-first) or against insulin (IAA-first). We profiled me...     »
Zeitschriftentitel:
Diabetes
Jahr:
2020
Band / Volume:
69
Heft / Issue:
3
Seitenangaben Beitrag:
465-476
Volltext / DOI:
doi:10.2337/db19-0756
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32029481
Print-ISSN:
0012-1797
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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