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Title:

Flow-metabolism uncoupling in patients with asymptomatic unilateral carotid artery stenosis assessed by multi-modal magnetic resonance imaging.

Document type:
Journal Article
Author(s):
Göttler, Jens; Kaczmarz, Stephan; Kallmayer, Michael; Wustrow, Isabel; Eckstein, Hans-Henning; Zimmer, Claus; Sorg, Christian; Preibisch, Christine; Hyder, Fahmeed
Abstract:
Oxygen extraction (OEF), oxidative metabolism (CMRO2), and blood flow (CBF) in the brain, as well as the coupling between CMRO2 and CBF due to cerebral autoregulation are fundamental to brain's health. We used a clinically feasible MRI protocol to assess impairments of these parameters in the perfusion territories of stenosed carotid arteries. Twenty-nine patients with unilateral high-grade carotid stenosis and thirty age-matched healthy controls underwent multi-modal MRI scans. Pseudo-continuou...     »
Journal title abbreviation:
J Cereb Blood Flow Metab
Year:
2019
Journal volume:
39
Journal issue:
11
Pages contribution:
2132-2143
Fulltext / DOI:
doi:10.1177/0271678X18783369
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29968499
Print-ISSN:
0271-678X
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Fachgebiet Neuroradiologie (Prof. Zimmer); I. Medizinische Klinik und Poliklinik (Kardiologie); Klinik und Poliklinik für Psychiatrie und Psychotherapie
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