User: Guest  Login
Title:

No benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review.

Document type:
Review; Journal Article; Review; Research Support, Non-U.S. Gov't
Author(s):
Furukawa, T A; Salanti, G; Cowen, P J; Leucht, S; Cipriani, A
Abstract:
BACKGROUND: In fixed-dose antidepressant trials, the lower range of the licensed dose achieves the optimal balance between efficacy and tolerability. Whether flexible upward titration while side-effects permit provides additional benefits is unknown. METHODS: We did a systematic review of placebo-controlled randomized trials that examined selective serotonin reuptake inhibitors (SSRIs), venlafaxine or mirtazapine in the acute treatment of major depression. Our primary outcome was response, defin...     »
Journal title abbreviation:
Acta Psychiatr Scand
Year:
2020
Journal volume:
141
Journal issue:
5
Pages contribution:
401-409
Fulltext / DOI:
doi:10.1111/acps.13145
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31891415
Print-ISSN:
0001-690X
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
 BibTeX