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Titel:

Efficacy of clozapine compared with other second-generation antipsychotic drugs in patients with treatment-resistant schizophrenia: protocol for a systematic review and individual patient data meta-analysis of randomised controlled trials.

Dokumenttyp:
Review; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Siafis, Spyridon; Schneider-Thoma, Johannes; Hamza, Tasnim; Bighelli, Irene; Dong, Shimeng; Hansen, Wulf-Peter; Davis, John M; Salanti, Georgia; Leucht, Stefan
Abstract:
INTRODUCTION: Guidelines recommend clozapine for treatment-resistant schizophrenia. However, meta-analysis of aggregate data (AD) did not demonstrate higher efficacy of clozapine compared with other second-generation antipsychotics but found substantial heterogeneity between trials and variation between participants in treatment effects. Therefore, we will conduct an individual participant data (IPD) meta-analysis to estimate the efficacy of clozapine compared with other second-generation antips...     »
Zeitschriftentitel:
BMJ Open
Jahr:
2023
Band / Volume:
13
Heft / Issue:
2
Volltext / DOI:
doi:10.1136/bmjopen-2022-064504
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36810167
Print-ISSN:
2044-6055
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie (Prof. Priller)
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