Benutzer: Gast  Login
Titel:

Clinico-genetic findings in 509 frontotemporal dementia patients.

Dokumenttyp:
Journal Article
Autor(en):
Wagner, Matias; Lorenz, Georg; Volk, Alexander E; Brunet, Theresa; Edbauer, Dieter; Berutti, Riccardo; Zhao, Chen; Anderl-Straub, Sarah; Bertram, Lars; Danek, Adrian; Deschauer, Marcus; Dill, Veronika; Fassbender, Klaus; Fliessbach, Klaus; Götze, Katharina S; Jahn, Holger; Kornhuber, Johannes; Landwehrmeyer, Bernhard; Lauer, Martin; Obrig, Hellmuth; Prudlo, Johannes; Schneider, Anja; Schroeter, Matthias L; Uttner, Ingo; Vukovich, Ruth; Wiltfang, Jens; Winkler, Andrea S; Zhou, Qihui; Ludolph, Alb...     »
Abstract:
Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains elusive. We investigated the spectrum of genetic causes and assessed the genotype-driven differences in biomarker profiles, disease severity and clinical manifestation by recruiting 509 FTD patients from different centers of the German FTLD consortium where individuals were clinically assessed including biomarker analysis. Exome sequencin...     »
Zeitschriftentitel:
Mol Psychiatry
Jahr:
2021
Band / Volume:
26
Heft / Issue:
10
Seitenangaben Beitrag:
5824-5832
Volltext / DOI:
doi:10.1038/s41380-021-01271-2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34561610
Print-ISSN:
1359-4184
TUM Einrichtung:
1367; 303; 55; 617; 702; Fachgebiet Nephrologie (Prof. Heemann); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Humangenetik; Klinik und Poliklinik für Psychiatrie und Psychotherapie; Lehrstuhl für Neurogenetik (Prof. Winkelmann); Neurologische Klinik und Poliklinik
 BibTeX