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Titel:

Medial Temporal Lobe Disconnection and Hyperexcitability Across Alzheimer's Disease Stages.

Dokumenttyp:
Journal Article; Review
Autor(en):
Pasquini, Lorenzo; Rahmani, Farzaneh; Maleki-Balajoo, Somayeh; La Joie, Renaud; Zarei, Mojtaba; Sorg, Christian; Drzezga, Alexander; Tahmasian, Masoud
Abstract:
 The posteromedial cortex (PMC) and medial temporal lobes (MTL) are two brain regions particularly vulnerable in Alzheimer's disease (AD). We have reviewed the spatiotemporal patterns of amyloid-β and tau accumulation, local MTL functional alterations and MTL-PMC network reconfiguration, and propose a model to relate these elements to each other. Functional and structural MTL-PMC disconnection happen concomitant with amyloid-β plaques and neurofibrillary tau accumulation within these same region...     »
Zeitschriftentitel:
J Alzheimers Dis Rep
Jahr:
2019
Band / Volume:
3
Heft / Issue:
1
Seitenangaben Beitrag:
103-112
Volltext / DOI:
doi:10.3233/ADR-190121
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31259307
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für Psychiatrie und Psychotherapie
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