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Titel:

Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.

Dokumenttyp:
Journal Article
Autor(en):
Timm, Kerstin N; Hu, De-En; Williams, Michael; Wright, Alan J; Kettunen, Mikko I; Kennedy, Brett W C; Larkin, Timothy J; Dzien, Piotr; Marco-Rius, Irene; Bohndiek, Sarah E; Brindle, Kevin M
Abstract:
Rapid cancer cell proliferation promotes the production of reducing equivalents, which counteract the effects of relatively high levels of reactive oxygen species. Reactive oxygen species levels increase in response to chemotherapy and cell death, whereas an increase in antioxidant capacity can confer resistance to chemotherapy and is associated with an aggressive tumor phenotype. The pentose phosphate pathway is a major site of NADPH production in the cell, which is used to maintain the main in...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2017
Band / Volume:
292
Heft / Issue:
5
Seitenangaben Beitrag:
1737-1748
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M116.761536
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27994059
Print-ISSN:
0021-9258
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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