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Title:

RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field.

Document type:
Journal Article; Review
Author(s):
Ludwig, Beatrice S; Kessler, Horst; Kossatz, Susanne; Reuning, Ute
Abstract:
Integrins have been extensively investigated as therapeutic targets over the last decades, which has been inspired by their multiple functions in cancer progression, metastasis, and angiogenesis as well as a continuously expanding number of other diseases, e.g., sepsis, fibrosis, and viral infections, possibly also Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Although integrin-targeted (cancer) therapy trials did not meet the high expectations yet, integrins are still valid and pr...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2021
Journal volume:
13
Journal issue:
7
Fulltext / DOI:
doi:10.3390/cancers13071711
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33916607
TUM Institution:
Frauenklinik und Poliklinik; Klinik und Poliklinik für Nuklearmedizin
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