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Title:

An in silico study on the effect of the radionuclide half-life on PET/CT imaging with PSMA-targeting radioligands.

Document type:
Article; Journal Article
Author(s):
Begum, Nusrat Jihan; Glatting, Gerhard; Eiber, Matthias; Beer, Ambros J; Kletting, Peter
Abstract:
AIM:  The aim of this work was to systematically investigate the influence of the radionuclide half-life and affinity of prostate-specific membrane antigen (PSMA)-targeting ligands on the activity concentration for PET/CT imaging. METHODS:  A whole-body physiologically-based pharmacokinetic (PBPK) model with individually estimated parameters of 13 patients with metastatic castration-resistant prostate cancer (mCRPC) was used to simulate the pharmacokinetics of PSMA-targeting radioligands. The si...     »
Journal title abbreviation:
Nuklearmedizin
Year:
2021
Journal volume:
60
Journal issue:
1
Pages contribution:
33-37
Fulltext / DOI:
doi:10.1055/a-1253-1535
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33137837
Print-ISSN:
0029-5566
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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