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Title:

Lymphocyte Infiltration Determines the Hypoxia-Dependent Response to Definitive Chemoradiation in Head-and-Neck Cancer: Results from a Prospective Imaging Trial.

Document type:
Journal Article
Author(s):
Nicolay, Nils H; Rühle, Alexander; Wiedenmann, Nicole; Niedermann, Gabriele; Mix, Michael; Weber, Wolfgang A; Baltas, Dimos; Werner, Martin; Kayser, Gian; Grosu, Anca-L
Abstract:
Tumor hypoxia in head-and-neck squamous cell carcinoma (HNSCC) leads to an immunosuppressive microenvironment and reduces the response to radiotherapy. In this prospective imaging trial, we investigated potential interactions between functional hypoxia imaging and infiltrating lymphocyte levels as a potential predictor for treatment response in HNSCC patients. Methods: In total, 49 patients receiving definitive chemoradiation for locally advanced HNSCCs underwent pretherapeutic biopsies and peri...     »
Journal title abbreviation:
J Nucl Med
Year:
2021
Journal volume:
62
Journal issue:
4
Pages contribution:
471-478
Fulltext / DOI:
doi:10.2967/jnumed.120.248633
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32859699
Print-ISSN:
0161-5505
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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