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Title:

Forecasting the Pharmacokinetics With Limited Early Frames in Dynamic Brain PET Imaging Using Neural Ordinary Differential Equation

Document type:
Article
Author(s):
Hong, Jimin; Brendel, Matthias; Erlandsson, Kjell; Sari, Hasan; Lu, Jiaying; Clement, Christoph; Bui, Ngoc Vinh; Meindl, Maria; Ziegler, Sibylle I.; Barthel, Henryk; Sabri, Osama; Choi, Hongyoon; Sznitman, Raphael; Rominger, Axel; Shi, Kuangyu
Abstract:
In dynamic brain positron emission tomography (PET) studies, acquiring a time series of images, typically lasting more than an hour, is necessary to derive pharmacokinetic parameters. Analytically, these parameters are estimated by establishing kinetic models such as compartment models that consist of sets of ordinary differential equations (ODEs), and by fitting the sparse time-activity curve (TAC) of the tracer. Yet, these models are simplified approximations of highly complex underlying proce...     »
Journal title abbreviation:
IEEE Trans. Radiat. Plasma Med. Sci.
Year:
2023
Journal volume:
7
Journal issue:
6
Pages contribution:
607-617
Fulltext / DOI:
doi:10.1109/TRPMS.2023.3253261
Print-ISSN:
2469-7311
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)
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