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Title:

Randomized phase-III-trial of concurrent chemoradiation for locally advanced head and neck cancer comparing dose reduced radiotherapy with paclitaxel/cisplatin to standard radiotherapy with fluorouracil/cisplatin: The PacCis-trial.

Document type:
Journal Article
Author(s):
Fietkau, Rainer; Hecht, Markus; Hofner, Benjamin; Lubgan, Dorota; Iro, Heinrich; Gefeller, Olaf; Rödel, Claus; Hautmann, Matthias G; Kölbl, Oliver; Salay, Attila; Rübe, Christian; Melchior, Patrick; Breinl, Peter; Krings, Waldemar; Gripp, Stephan; Wollenberg, Barbara; Keerl, Rainer; Schreck, Ulrike; Siekmeyer, Birgit; Grabenbauer, Gerhard G; Balermpas, Panagiotis
Abstract:
BACKGROUND AND PURPOSE: This multicenter, phase 3 trial investigates whether the incorporation of concurrent paclitaxel and cisplatin together with a reduced total dose of radiotherapy is superior to standard fluorouracil-cisplatin based CRT. MATERIALS AND METHODS: Patients with SCCHN, stage III-IVB, were randomized to receive paclitaxel/cisplatin (PacCis)-CRT (arm A; paclitaxel 20 mg/m2 on days 2, 5, 8, 11 and 25, 30, 33, 36; cisplatin 20 mg/m2, days 1-4 and 29-32; RT to a total dose of 63.6...     »
Journal title abbreviation:
Radiother Oncol
Year:
2020
Journal volume:
144
Pages contribution:
209-217
Fulltext / DOI:
doi:10.1016/j.radonc.2020.01.016
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32044419
Print-ISSN:
0167-8140
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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