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Titel:

Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lechner, Antonie; Henkel, Fiona D R; Hartung, Franziska; Bohnacker, Sina; Alessandrini, Francesca; Gubernatorova, Ekaterina O; Drutskaya, Marina S; Angioni, Carlo; Schreiber, Yannick; Haimerl, Pascal; Ge, Yan; Thomas, Dominique; Kabat, Agnieszka M; Pearce, Edward J; Ohnmacht, Caspar; Nedospasov, Sergei A; Murray, Peter J; Chaker, Adam M; Schmidt-Weber, Carsten B; Esser-von Bieren, Julia
Abstract:
BACKGROUND: Infectious agents can reprogram or "train" macrophages and their progenitors to respond more readily to subsequent insults. However, whether such an inflammatory memory exists in type 2 inflammatory conditions such as allergic asthma was not known. OBJECTIVE: We sought to decipher macrophage-trained immunity in allergic asthma. METHODS: We used a combination of clinical sampling of house dust mite (HDM)-allergic patients, HDM-induced allergic airway inflammation in mice, and an in vi...     »
Zeitschriftentitel:
J Allergy Clin Immunol
Jahr:
2022
Band / Volume:
149
Heft / Issue:
6
Seitenangaben Beitrag:
2078-2090
Volltext / DOI:
doi:10.1016/j.jaci.2021.11.026
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34974067
Print-ISSN:
0091-6749
TUM Einrichtung:
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg); Lehrstuhl für Molekulare Allergologie und Umweltforschung (Prof. Schmidt-Weber)
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